Formulasi dan Uji Aktivitas Antivaakteri Gel Ekstrak Daun Tapak Liman (Elephantopus scaber L.) Terhaadap Bakteri Stapylococcus aureus ATCC 25923

ADILA, AULIA NISA (2025) Formulasi dan Uji Aktivitas Antivaakteri Gel Ekstrak Daun Tapak Liman (Elephantopus scaber L.) Terhaadap Bakteri Stapylococcus aureus ATCC 25923. S1 thesis, Universitas PGRI Madiun.

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Abstract

Acne is a skin disorder caused by bacterial infection, particularly Staphylococcus aureus. The increasing resistance to conventional antibiotics has encouraged the development of natural-based formulations as alternative treatments. Elephantopus scaber L. leaves are known to contain active compounds such as flavonoids, alkaloids, steroids, and terpenoids, which have potential antibacterial properties. This study aimed to formulate an ethanol extract gel of E. scaber leaves at concentrations of 5%, 10%, and 15%, and evaluate its antibacterial activity against Staphylococcus aureus ATCC 25923 using the disk diffusion method. The gel formulations were assessed for their physical characteristics, including organoleptic properties, pH, homogeneity, viscosity, spreadability, stability, and hedonic (user preference) testing. The results showed that all gel formulations met the required physical characteristics, and the formulation containing 15% extract demonstrated the highest antibacterial activity with the largest inhibition zone against Staphylococcus aureus. Therefore, the gel of E. scaber leaf extract has potential to be developed as a natural topical antibacterial formulation.

Item Type:	Thesis/Skripsi/Tugas Akhir (S1)
Kata Kunci:	Gel, Tapak Liman (Elephantopus scaber L.), Antibakteri, Staphylococcus aureus, Difusi cakram.
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Ilmu Kesehatan dan Sains > Farmasi
Depositing User:	ADILA NISA AULIA
Date Deposited:	03 Sep 2025 05:30
Last Modified:	03 Sep 2025 05:30
URI:	http://eprint.unipma.ac.id/id/eprint/4795

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